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Acylation reagents for GC - Bisacylamides

Macherey-Nagel GmbH & Co. KG (15132)

Acylation reagents for GC - Bisacylamides
For improved volatility, better thermal stability or low limit of detection in gas chromatography prerequisite: quantitative, rapid and reproducible formation of only on derivative halogen atoms introduced by derivatisation (e.g. trifluoroacetates) allow specific detection (ECD) with the advantage of high sensitivity elution order and fragmentation patterns in MS can be influenced by a specific derivatisation.
Reagents for silylation - alkylation (methylation) - acylation are available.
Acylation with fluorinated acid amides is recommended for alcohols, primary and secondary amines as well as for thiols under mild, neutral conditions. MBTFA also forms very volatile derivatives with carbohydrates.

by-products: corresponding neutral acylamides, which can be easily removed due to their high volatility; because of neutral conditions and favourable chromatographic properties often removal of the bisacylamide is not necessary. Thus sample preparation is much more convenient.

MBTFA / MBHFBA
N-methyl-bis(trifluoroacetamide) MBTFA
m.w. 223.08, Bp 123 - 124°C (760mm Hg), density d20°/4° = 1.55,
CF3 - CO - N(CH3) - CO - CF3

PN	Manuf. PN	Supplier	Capacity~ml	Description	PK	General	Price
7510796	701410.110	Macherey-Nagel GmbH & Co. KG	10	MBTFA	1	Dangerous substance	Inquire
6228605	701410.510	Macherey-Nagel GmbH & Co. KG	10	MBTFA	5		1014.71 EU
7401143	701410.201	Macherey-Nagel GmbH & Co. KG	1	MBTFA	20		519.12 EU